In this sequel to the controversial PBS mini-series, Mona Ramsey is on a cross-country trip that takes her to a brothel which may hold a secret about her past. Michael "Mouse" Tolliver and Mary Ann Singleton go on a cruise where they meet up with lovers old and new. Back in San Francisco, Brian Hawkins becomes involved with a mysterious woman he spots from his window, while DeDe Halcyon Day becomes acquainted with a new friend who helps her discover her true inner feelings.

This third installment to "Tales of the City" finds Mary Ann Singleton struggling to advance in her new career as a TV personality, while Michael Tolliver is playing the field after his break-up with Jon Fielding. After her divorce, Prue Giroux finds comfort in a mysterious stranger she meets in the park. Brian Hawkins is struggling with his job and his new monogamous relationship with Mary Ann, and DeDe Halcyon Day returns with a dangerous revelation that could be the scoop Mary Ann has been waiting for.

泽德期待着获得体育奖学金，而艾迪生正在为西布鲁克的国际助威比赛做准备。然后，突然，外星生物出现在西布鲁克周围，这不仅仅是友好的竞争。