In every man there lies a woman who can be awakened. The prohibited book De Serpentis Munere. Alchemical formulae able to change male DNA in female. Mysterious radioactive water. A biologist and a Vatican priest in search of the truth.

The year is 2047. Our planet is ruled by the repressive Confederate Central Government (CCG). Ryan is a Green War rebel agent sent on a mission by Sponge (Danny Glover) to collect evidence against the CCG for its heinous crimes. Ryan soon faces the sinister Colonel Asimov, Major Anderson and a group of mercenaries lead by Lobo. Ryan's mission quickly turns chaotic when he meets Tuage, a mutant survivor of the CCG rebellion who swears to help Ryan save what is left of their world - or does she?