Gigi and Marlene, two single women both in their late 20's, work at a bio-technology company, researching and developing medicine to suppress specific genes and observe their effects on the human body. Gigi is born with the "clean-freak" gene and her obsession with keeping things tidy causes problems in her relationships. Marlene, on the other hand, is born with the "fat gene" and needs to regularly take pills to maintain her weight. Marlene panics when she learns that her "anti-fat" pills will be taken off the market. Their personal problems coincide with romantic ones. Marlene grows frustrated maintaining her long-distance relationships via the Internet, and Gigi leaves her boyfriend when she discovers he's cheating on her.

朵朵出生的时候，老天并没有赋予她一双可以走路的脚。然而她的生命中没有缺少父母的爱，她接受手术后获得一双可以走路的脚，并获得了她生命中的第一双鞋。她相信巫婆的预言，相信黑羊和白羊会带给她幸福。但是在日常的生活中朵朵不停的搜集美丽的鞋子以致要专门用一间屋子存放。 长大后的朵朵（徐若瑄饰），到了童话书籍出版社上班，她爱童话也爱幻想。透过神秘插画家的介绍，她认识了牙医诊所的主治医师，一名微笑牙医（周群达饰）。最后借着黑羊与白羊的牵引，他们结了婚，走进了幸福的生活。但是一场意外突然到来……