In the distant future, mankind lives on Mars, in cities that resemble those once found on Earth, protected from the alien atmosphere by dome-like force-fields. When a massive sandstorm breaks through the dome and destroys Mars New York, those in Mars Los Angeles must figure out how to stop the storm before it wipes them out next.

In an abandoned mental institution, doctors carry out secret experiments on unsuspecting patients. The experiments, codenamed Limes, are designed to cure violent episodes within the inmates through new methods of brainwashing and mind manipulation. It is soon discovered by the families of the patients that this is no ordinary hospital.