One year has passed after the great battle against the Orochi (gigantic snake). Tenka Kumo had been paralyzed from the final battle and he took part of the government’s human experiment before the battle. Tenka withdrew himself from society but his younger brothers Soramaru and Chutaro find out the secret past about their older brother.

Fuma ninja clan is a secret ninja tribe that is waiting for the "Orochi" (gigantic snake) to resurrect for generations. Shirasu and his twin brother Ichiu grew up in this viscous environment and this tells how they become the leaders of the clan.