When a Black doctor develops a serum that is supposed to regenerate dying liver cells and tests it on himself, it accidentally turns him into an albino monster with a lust for murdering prostitutes, pimps and drug dealers.

Eddie Warmack, an African American jazz musician, is released from prison for the killing of a white gangster. Not willing to play for the mobsters who control the music industry, including clubs and recording studios, Warmack searches for his mentor and grandfather, the legendary jazz musician Poppa Harris.