Nanami is a senior in college and thick in the hunt for work. Her dream is to work in the flamboyant field of media, but she has yet to receive any offer. When her best friend, Tomoko, lands a position, she becomes frustrated and takes it out on her boyfriend, Ishino. One day, coming across a wanted flyer of a housemaid, she goes to a mansion of the Kiuchis, who have put out the ad. Luckily, she is hired and starts the job as a resident housemaid on the spot. However, things begin to look weird when Koichiro, the son, hands her a maid costume.

A female office worker grows tired of her popular and attractive colleague's office affairs, and releases explicit footage of her as revenge.

吉川あいみ、範田紗々ほかセクシー女優たちが多数共演する「脱衣麻雀」シリーズ第3弾。あるウイルスの秘密を知ってしまった女医・観月。院長は秘密を知り過ぎた彼女を捕え、医療法で禁止された“脱衣麻雀臨床実験”によって始末しようとする。