Karl Heinrich is the heir to the throne of the small European principality of Rutania, but he's a lonely child, not allowed to play with other children and knowing little about life outside the castle. When he reaches maturity, he is sent to attend the University of Heidelberg, and finds fellowshi with classmates and a blossoming love with Katie Ruder, his only friend during childhood and the niece of an innkeeper. However, political turmoil in Rutania forces him to return. War is declared. Heinrich returns to Heidelberg one last time to bid a somber farewell to his beloved Katie.

Coke Ennyday, the scientific detective, divides his own time in periods for "Sleep", "Eat", "Dope" and "Drink". In fact he's used to overcome every situation with drugs: consuming it to increase his energies or injecting it in his opponents to KO them. To help the police he discovers a contraband of opium (which he eagerly tastes) transported with "Leaping Fishes", and the blackmail of a mysterious man who wants to marry the "fish blower" girl. Will Coke be able to free the girl ?