故事围绕着“Odette”、“Clarice”以及“Barbara Jean”三人展开，她们相识于高中，成立了叫做“The Supremes”的闺蜜组，如今已经携手了走过了四十多年的友情岁月。而位于印第安纳州Plainview的餐厅，就是她们的另一个家；在这里她们分享那些关于婚姻、孩子、快乐、忧伤等种种事情，并携手经历来自生活里种种的风暴。而对三姐妹来说，最具挑战性的一年刚刚到来：骄傲、才华横溢的Clarice面对丈夫可耻的不忠行为时，努力让生活正常；美丽的Barbara Jean被一段年轻恋情所造成的悲剧性影响所震撼，而向来无畏的Odette则即将踏上此生最恐怖的战斗。

Set in Detroit during the Civil Rights Movement, "An American Girl Story - Melody 1963: Love Has to Win" examines the joyful life and troubled times of an irrepressible 10-year-old African-American girl whose vivid imagination and creativity reinforce her optimism. When shocking national events threaten her sense of security, Melody must find inner strength to restore her hope for a better world.

Three poor Black kids in rural Mississippi reap the consequences of their family's cycle of abuse, addiction, and violence.