Coach George Copper's college football team is losing game after game, much to the dismay of stiff-and-stuffy but influential alumni Roger Jessup, and also having trouble at home with his oldest daughter, Connie. The team keeps losing and Coach Cooper is about to lose his job as his efforts to win the last game of the season, against the team's Big Rival, end in disaster. But, unknown to he and his wife, Elizabeth, Connie has sold an article, called "I Was a Bubble Dancer" to a 'True-Confession" magazine, and the girl-who-couldn't-get-a-date becomes suddenly popular and, because of her, the high-school football star from another town decides to play his college-ball for Coach Cooper. Jessup is forced to keep Cooper on as the school's football coach.

A ladies' man flirts with the wives of other governments' officials.

John and Irene Emerson's marriage begins well enough, but it is not long before John becomes less attentive. Feeling neglected, Irene spends more time with her girl friends, and John, consequently, falls prey to the vamping wiles of his secretary, Jean Ralston. When John comes home from the theater smelling of Jean's perfume, Irene procures a divorce; John then marries Jean.

A woman's love for and devotion to a married man results in her being relegated to the "back streets" of his life.

The life of spoiled Robert Merrick (Robert Taylor) is saved through the use of a hospital's only pulmotor, which results in the death of Dr. Hudson, a selfless, brilliant surgeon and generous philanthropist. Merrick falls in love with Hudson's widow, Helen (Irene Dunne), though she holds him responsible for her husband's demise. One day, he insists on driving her home and makes a pass at her. She gets out and is struck by another car, losing her sight.
He watches over her and visits her during her recuperation, concealing his identity and calling himself Dr. Robert. When he finds out that she is nearly penniless, he secretly pays for specialists to try to restore her vision. Finally, she travels to Paris and is told that her eyesight is gone forever. Robert follows her, confesses his true identity and proposes marriage. She forgives him, but goes away, not wanting to be a burden to him.
Years later, Robert has become a brain surgeon. He learns that Helen urgently needs an operation, which he performs. When she awakens, her sight has miraculously returned.