From the onset of the AIDS epidemic, author Larry Kramer emerged as a fiery activist, an Old Testament-style prophet full of righteous fury who denounced both the willful inaction of the government and the refusal of the gay community to curb potentially risky behaviors. Co-founder of both organization Gay Men's Health Crisis and the direct action protest group ACT UP, Kramer was vilified by some who saw his criticism to be an expression of self-hatred, while lionized by others who credit him with waking up the gay community — and, eventually, the government and medical establishment — to the devastation of the disease.

Describing herself as a 'street queen,' Johnson was a legendary fixture in New York City’s gay ghetto and a tireless voice for LGBT pride since the days of Stonewall, who along with fellow trans icon Sylvia Rivera, founded Street Transvestites Action Revolutionaries (S.T.A.R.), a trans activist group based in the heart of NYC’s Greenwich Village. Her death in 1992 was declared a suicide by the NYPD, but friends never accepted that version of events. Structured as a whodunit, with activist Victoria Cruz cast as detective and audience surrogate, The Death and Life of Marsha P. Johnson celebrates the lasting political legacy of Johnson, while seeking to finally solve the mystery of her unexplained death.