A naïve young girl desperate to fit in with her new boyfriend's tightly knit crew learns that membership may be deadly. Upon arriving at a party with her new boyfriend, Shawn, desperate-to-fit-in newcomer Debbie learns that the friends have formed a mysterious brotherhood nicknamed "The Murder Club." As Debbie accepts her invitation to join the mysterious club, a murderer who seems to take the group's name to heart begins killing off members one by one.

Mother Fitch (Julie Strain) and her girls have an insatiable taste for men; their flesh that is. The Delta Delta Pi sorority girls are not only the most popular and wealthy on campus, but also the most deadly. Now, as they prepare for their 20th anniversary homecoming, a meddlesome student has enlisted the help of DDP charter member Rhonda Cooper (Brinke). Together they attempt to end the sorority's reign of culinary terror that grips the California campus.