Due to violent crimes becoming more and more complicated, it is crucial to make arrests with concrete evidence. The White Lab is the formed within the Tokyo Metropolitan Police Department’s First Investigative Division. The lab uses scientific investigation methods involving physics, chemistry, biology and medical science to solve cases. Members of the White Lab have knowledge of these scientific areas and have the authority to investigate cases.

In 1990, Hagizaki Tatsuo, the accounting department chief of Ukishima Electric Works, was busy negotiating on getting a loan together with Sekino, the company's general manager. However, just as they were about to get the funds, Sekino was involved in a 200 million yen fraud and he later disappeared with the loan. The company decides to cover up the incident to protect its image, but Hagizaki wants to get to the bottom of the matter with the help of his newspaper reporter friend, Muraki. Hagizaki later notices that the case becomes darker and darker as he continues to investigate. He then meets a beautiful woman, Uezaki Etsuko, whom he believes hold the key to the entire incident.