1961年，一块叫“atmosphereum”的矿石坠落在在洛杉矶郊外的一个山上，勇敢的科学家决心用这块矿石来发展科学事业，他的妻子和他开始了寻找矿石的旅程。他们预见了一对可爱的从Marva星来的外星人夫妇。这对外星夫妇需要矿石来当他们飞船的燃料。在小山上还有一个脸谱式的邪恶科学家正在探索Cadavra洞穴，以期望发现传说中的“失落的遗骸”。碰巧，矿石可以使得“失落的遗骸”复活过来，于是这个邪恶的科学家也加入了夺矿之争。邪恶科学家偷了外星夫妇飞船上的光线枪，他利用光线枪把四个动物合成了一个女人，当自己的老婆……

THE LOST SKELETON RETURNS AGAIN takes on a whole new series of clichés, primarily drawn from those low budget adventure epics -- rich in potted ferns and stock footage -- that thrived on cheap back lots from the early 30s to the late 50s. It also wanders beyond the narrow confines of jungle pictures, parodying everything from gangster movies to those Mondo films of the 1960s, with their salacious native dances.

A small town infestation of crawling alien foreheads that begin attaching to people and taking them over collides with a scientist's experiments to extract foreheadazine and things go horribly horribly wrong.