One day, while conducting such smuggling, they lose the transaction slip - a Rs. 2 note. The film "Dui Rupaiyan" entails their quest to find that Rs. 2 and save their necks, all the while saving themselves from local thugs, police, and their boss too.

The film tells the story of three childhood friends. The trio all had dreams to fulfill 'when they grew up', but time and destiny seem to have other plans for them. A difficult life is forced upon them when the elder brother of one of these three men is hit by the vehicle of a shady character called Chewang and left completely paralyzed. The three friends then find themselves in the way of a criminal gang called 'Royal', of which Chewang is the leader.