One week before proposing to his girlfriend, Kyle, a down-on-his-luck romantic, discovers that she's been sleeping with another man. Unemployed, saddled with debt, and depressed, Kyle embarks on a funny yet affecting journey to recovery that involves living in his car, bottom-of-the-barrel jobs, therapy, online dating, and Kyle's own wild, fantastical, and snarky imagination.

When their plans for a nature trip go awry, Polly and boyfriend Seth decide to check into a motel. On their way, they're carjacked and kidnapped by low-rent crooks Dennis and Lacey, who take the victims and their SUV to a nearby gas station. Along the way, they encounter an increasingly terrifying horde of parasites, and if any of them intend to survive, they'll have to outsmart the deadly organisms.