Two couples and friends, Ale and Santi and Natalia and Mario, are celebrating their twenty years together by holidaying in the Caribbean. They catch up with each other's news, drink, reconnect... Ale, tipsy on the rum, decides to admit that the night the four met one another, she had played her hand to end up with Santi, who had initially fancied Natalia. The news doesn't get the expected response. The following morning, Ale gets up with a horrible hangover and absolutely no idea of the extent to which she will have to face the consequences of her action.

年轻漂亮的美国女护士艾米·尼古拉斯（卡莉丝塔·弗洛克哈特 Calista Flockhart 饰）受命来到英国怀特岛一家老旧的仁爱医院，担当这里的夜班护士。此前，仁爱医院的孩子们已经准备好转到条件更为优秀的圣詹姆士医院，但一场严重的火车事故导致圣詹姆士人满为患，仁爱的搬迁计划暂时搁浅。艾米抵达这里，很快就注意到恬静又有几分神秘的小女孩麦琪（耶斯敏·墨菲 Yasmin Murphy 饰）。从麦琪的言语以及医护人员的诡异举止，艾米隐隐感到这所医院隐藏着不为人知的秘密。而当夜幕降临，恐怖的事情果然随之发生…… 本片荣获2006年巴塞罗那电影节最佳摄影和最佳剪辑奖；2006年歌雅奖最佳特效奖；2006年Gerardmer电影节观众奖、评委会特别奖、青年评委会大奖。