Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.

　　该剧讲述了两个早熟的四年级小学生——乔治·比尔德（George Beard）和哈罗德·哈钦斯（Harold Hutchins）利用催眠术把他们的讨厌校长本尼·克鲁普（Benny Krupp）先生变成了穿着内裤的超人——“内裤队长”！这个内裤超人对孩子们很友善，总是能帮他们摆脱各种麻烦，但一旦恢复清醒，就会忘了自己作为“内裤队长”所做过的事情。

改編自美國著名暢銷童書半狗半人的超狗神探，在全力追捕邪惡壞蛋貓皮皮的同時，誓言保護和服務社會。