Lyle, sick of his girlfriend's annoying laugh, wants to end their relationship. Too scared to do it honestly, he enacts a scheme to convince her that they must break up because he is at the center of an epic battle between man, beast and fowl. Unfortunately, it all goes according to plan in this epic comedy filled to the brim with twists and turns.

一个害羞的大学生和他鲁莽的室友开始了一个简单的任务去拿披萨，但在服用了一剂奇怪的令人心智的实验药物后，他们陷入了一个混乱的夜晚，荒谬的遭遇、疯狂的幻觉和意外的启示，这些启示可能会永远改变他们的生活。