A kindly, elderly couple who run a New York City boarding house form the steady center around which the lives and loves of their various residents unfold. Borrowed money, a lovelorn chorus girl, and a tragic misunderstanding set in motion the chain of events in East of Fifth Avenue’s tender pageant of life.

Herman Brandt, a handsome but overly conceited actor, lives in the same apartment building in Vienna as Carola and John Pointer and their 18-year-old daughter Mariette. One day, as Carola leaves the building, Brandt catches her in the stairwell and proposes she "visit" him at his apartment after everyone has gone to bed. Shocked and offended at his brazenness, she complains to the building manager, who orders Brandt to leave. He refuses, so the Pointers decide that they will move out instead. While they're packing, the police show up at their apartment with some bad news--Brandt has been found murdered, shot in the head. Inspector Muller, the detective investigating the murder, discovers that there is more to this case than meets the eye.

A young woman marries a man who turns out to be a bank robber.

John Evans encounters his lookalike, Malcolm Scott. When Scott is killed in an accident, Evans finds himself mistaken for Scott and decides to do some good in his new role.

Mary Scott learns she only has ten months to live before dying of an incurable disease. She manages to keep the news from her husband, Brad and daughter, Polly. She tries to make every moment of her life count, but her effort is weakened by the discovery that Brad is interested in his assistant, Chris Radner. But when she learns that Brad does indeed love her and not Chris, and that Chris is leaving town, she realizes what she must do to ensure the future happiness of Brad and Polly. She persuades Chris to stay, makes a genuine friend of her and watches Polly grow towards Chris.

A team of ex-con bounty hunters go to Germany in search of Hitler. If they can find him, a million dollar reward is to be paid to them.