Crimes of the Future is set in a future where sexually mature women appear to have been obliterated by a plague produced by the use of cosmetics. The film details the wanderings of Adrian Tripod, director of the dermatological clinic the House of Skin. Tripod seems at a loss following the disappearance of his mentor Antoine Rouge.

A group of Canadian university students agree to partake in a grisly psychological experiment, which renders them incapable of speech but able to communicate telepathically.