The journey of young, handsome New York City playboy Sam Wellman - man’s man and professional woman hater – and his relationship with Doc, his best (and only!) friend. One strange, drunken night Sam stumbles into an Old Curiosity Shop, where the elderly proprietor offers him tea along with sage advice on treasuring “the female of the species”. Sam awakens the next morning to find himself transformed into a woman.

Hoping to leave behind the trauma of her mother's death, a young woman moves to New York City, where she becomes close to her similarly haunted roommate -- until a disturbing revelation changes everything.

Frankie is head strong and passionate about her rock band and her Italian-American heritage. She is engaged to a good Italian man, and everything in her life is in order until she discovers a murder victim in the trunk of her rental car. Heather, her sister, convinces Frankie to attend the funeral where they meet Nicolette, the daughter of the new Brooklyn mafia don. When Nicolette shows up at a gig, it triggers a cascade of events that take Frankie towards an unexpected romance.