Following the Civil War, Confederate Captain Justice Cain has retired to a quiet life with his young son and black wife. However, the men of his old outfit, known as Cain's Cutthroats, have turned to lives of murder, torture and robbery. They attempt to convince Cain to ride with them once more. He refuses, and the Cutthroats murder his family. Swearing vengeance, Cain teams up with a colorful preacher/bounty hunter, and hunts down his family's killers one at a time.

Detective Lt. Dan Bradley (Duke Moore) interrupts his opera night to investigate strange sightings of ghosts at a remote farmhouse where a mad doctor had experimented with monsters several years earlier (Bride of the Monster?) Along with him goes faint-hearted patrolman Kelton (Paul Marco). What they find is that fake spiritualist Dr. Karl Acula (Kenne Duncan) is running a spiritualist con game, bilking people into thinking they can contact dead relatives for a hefty fee. Karl's conniving girlfriend Sheila (Valda Hansen) cruises the grounds like a ghost for an undisclosed reason, as well, and the Karl has the goonish, giant Lobo (Tor Johnson, apparently survived from the previous film with gross facial scars) for use as a henchman. As the cops close in on Karl's racket, it becomes clear that there are other ghosts haunting the premises - that aren't Dr. Acula's cheap illusions.