When queen Victoria visits president Grant, the old and new world leaders brag and sneer, ending up to bet who can catch the Daltons first, her P.I. Sherlock Holmes or U.S. top-sleuth Lucky Luke. While the champions with opposite manners and methods play fair, Victoria follows in a cart with two guardsmen, which she orders to sabotage Lucky. Just when she snatches up Sherlock to rebuke him, that gets the whole British party kidnapped by the Daltons..

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朱利安·莫尼耶Julien Monnier（弗朗索瓦-格扎维埃·德迈松饰）是一名成功的两性顾问和婚姻问题专家，他在事业上一帆顺风，但在实际生活中，对两性问题并不像他研究的那般应对自如，相反却是频频触礁，任何一个女人都没发在他的生活中停留两周以上——因为他身上好像有霉运病菌，谁和他在一起，都会变成世界上最囧的倒霉蛋。现在，他遇见了若阿娜·索里尼Johanna Sorini（维尔日妮·埃菲拉饰），并深深爱上了她，但这个女人是否能帮他打破恋爱魔咒呢……