Ricardo Caicedo’s perfect life as a successful businessman is shattered when an explosion rocks the El Nogal social club on the very night he was supposed to attend a business dinner.

“Mom of Number 10” tells the story of Tina Manotas, a beautiful and humble woman forced to leave her hometown because of problems his husband Edwin gets involved in. Already in the big city, Edwin abandons her with their two sons, and she must overcome difficulties and lack of money. She’ll sacrifice everything to make her son Victor’s dream of becoming a professional football player come true. Although the financial situation gets more complicated each day, Victor makes his mother a promise: “With my football I will buy you a palace, dear mother, I will take you to the sky”. Several years later, her son manages to buy her an apartment at the Sky Building. However, problems will start with elitist neighbors that feel envious of Tina Manotas’ new and luxurious life.

Garcia has managed to accomplish his wedding promise to his wife, Amalia: buy her a wretched farm outside the city, which is far from his wife's dream. But life turns unexpectedly as he arrives home and finds Amalia missing.