23 year-old Jimmy Ray is a small-time drug dealer bent on self-destruction. The product of broken home, Jimmy refuses help from those around him and spends his final hours hanging out and selling drugs (with, of course, an occasional robbery).

Dorian Shanley, is a heart surgeon who abuses alcohol and drugs. Dorian trades stolen pharmaceuticals for cocaine , provided by his best friend and enabler, Teddy. While Dorian's life and career take a nosedive, Shanley numbs the pain of losing his father, William Shanley, to a form of Alzheimer's common in prizefighters. To further complicate circumstances, Dorian falls in love with his girlfriend's best friend from college, Anna. The film follows Shanley through a maze of pharmacies, clubs and binges and surgeries, into the heart of drug abuse