The film centers on Howard F. Howard, an overweight everyman. Engaged to Beverly, the woman of his dreams, Howard has one problem - an overactive fixation with The Three Stooges. Everywhere Howard goes, he sees Moe, Larry, Curly, and Shemp intruding on his life. Determined to overcome his fixation, Howard and Beverly prepare for their wedding. But on his way to the ceremony, Howard descends into Stoogemania and finds himself walking into the city streets with other Stoogemaniacs. His only hope is commitment to the Stooge Hills sanitarium, under the care of a renowned psychologist, until the inmates take over the asylum on graduation day.

Scottsville is a sleepy town, where the yearly apple blossom festival is usually the only 'memorable' event, so Police Chief Sam Taylor is furious when young cop Ally Parks -who comes from the big city- insists on investigating the death and mutilation of prof. Fuller, who experimented on bats, and soon several other victims, as unnatural bat attacks. She finds a helpful 'expert' in animal controller Dr. John Winslow, and the couple gets help from his inquisitive daughter Genny and her practically in-living high school-friend Logan to unravel how it all ties in with local real estate mogul Carl Hart's dishonest and corrupt practices.