In ancient times, the immortal Fuxi, the King of Humankind, desired to create a paradise called the Eternal Country in the human world. However, he came into conflict with his lover, the goddess Yaochi Shengmu (Holy Mother of the Shining Lake), because the latter's mission is to bring death and disease upon humankind. Fuxi eventually broke up with Yaochi Shengmu and started a new relationship with Chang'e under his alter ego, Houyi. However, he lost Chang'e when she flew to the moon after consuming a magic pill from Yaochi Shengmu. Fuxi blamed Yaochi Shengmu for separating him and Chang'e, and fought with his ex-lover. The elders of the Pangu clan intervened by imprisoning Yaochi Shengmu in Heaven while Fuxi remains in the human world. Fong Tin-yau and Ma Siu-ling are living happily in Heaven after their success in 2001. However, in 2004, Yaochi Shengmu breaks free and introduces a deadly virus to wipe out the entire Pangu clan.

An exorcist heir and an immortal from the Blood Tribe cross paths during an investigation, uncovering past-life entanglements while uniting to stop a powerful villain’s plan to take over the world.

“驱魔龙族”马氏家族第四十一代传人马小玲，肩负着除邪惩恶的家族使命。而私家侦探况天佑，凭借奇特能力且容颜不老的身份屡破奇案，但实际上他一直在掩饰着基因突变后具有渴血冲动的“夜行者”身份，本来相安无事的日子，被一道“暗影”打破，两人在调查一起暗影袭击事件中相遇，出生入死的瞬间，百年恩怨所结下的宿命之锁，似乎已悄然解开……

大唐元年，天下繁盛。然而一段有关“七世怨侣”的预言，却使众人惶惶不得终日。传说魔道将凭七世怨侣的力量而得天下，人间从此化作无间地狱。玄心正宗的宗主燕赤霞（元华饰）尽展平生所学和魔君六道（罗嘉良饰）大战，魔君六道被燕赤霞杀死，留下一子七夜（聂远饰）。二十年后，一介书生宁采臣（陈晓东饰）来到有妖孽作崇的南郭镇。在入镇以前，宁采臣就接连遇见了很多离奇之事。先是被装神弄鬼的狐妖聂小倩（徐熙媛饰）吓个半死，然后又遇到一个叫人摸不着头脑的神秘少女马红叶（宣萱饰）。入镇以后，更被一个自称燕赤霞首席弟子的诸葛流云（吴京饰）苦缠。因缘际会，在冥冥中的安排下，一场凄美的人鬼情悲情上演。 由亚视著名鬼才编剧陈十三执导的古装奇幻电视剧《倩女幽魂》，根据我国经典名著聊斋的故事《聂小倩》改编。这部多地区合拍版剧集，两岸三地众星加盟，重新演绎一段至死不渝的真爱故事。