Set in 1964, a three-day journey along Route 66 begins when Bobby Falls, a 19-year-old serial killer, hitches a ride with Jim Goodwin, a celebrity animal handler travelling with his precious cargo: his TV chimpanzee, Spanky.

患有开放空间恐惧症的少女海泽（贝拉索恩 饰）在前往疗养中心途中，于荒野遭到两名蒙面暴徒袭击，受困车内，生死一线间。现在，海泽除了必须想尽办法自这场劫难中存活下来外，还必须克服内心逐渐滋生蔓延的恐惧心魔……