An assassin is shot by her ruthless employer, Bill, and other members of their assassination circle – but she lives to plot her vengeance.

Strange phenomena surface around the globe. The skies ignite. Terror races through the world's major cities. As these extraordinary events unfold, it becomes increasingly clear that a force of incredible magnitude has arrived. Its mission: total annihilation over the Fourth of July weekend. The last hope to stop the destruction is an unlikely group of people united by fate and unimaginable circumstances.

The Bride unwaveringly continues on her roaring rampage of revenge against the band of assassins who had tried to kill her and her unborn child. She visits each of her former associates one-by-one, checking off the victims on her Death List Five until there's nothing left to do … but kill Bill.