Charles Starrett once more dons the mask of mysterious do-gooder "The Durango Kid" in Columbia's Challenge of the Range. Wandering cowboy Steve Roper (Starrett) is hired by the Farmers Association to stem the activities of a group of gunmen who are driving ranchers off their land. The most likely suspect turns out to be innocent: the real culprits are within the Association itself. With the help of the chief suspect's son, Roper brings the crooks to justice.

Danny Mitchell and his canine pal Rusty befriend blind girl Penny Moffatt. Feeling cheated by life, Penny resists all efforts to cope with her handicap. But with Rusty's help, the girl gains a new lease on life and agrees to adopt a seeing-eye dog.

In the late 1880s, Colonel Carrington and his command are assigned the job of constructing a chain of forts in the Sious Indian territory of Wyoming. Carrington recruits former cavalry scouts Jim Bridger and "Dakota Jack" Gaines to lead the project. Bridger and Gaines are friendly with Sioux chief Red Cloud, and they feel a peace treaty with the Indians can be made. If an Indian-war breaks out, the cavalry is depending on getting a new type of Springfield rifle. Bridger, Gaines and Gaines wife, Maxine, arrive at the fort for the conference. Gaines, in a drunken fit, tries to intimidate the Indians unto signing a treaty. Chied Red Fox threatens war if his territory is invaded by any troops building forts.

Napoleon Solo is captured by Thrush and replaced with a double.

A scientist spills a new serum in his lab, accidentally inhales its fumes, and turns into a murderous monster who kills anyone he touches.

Count Dracula and his wife capture beautiful young women and chain them in their dungeon, to be used when they need to satisfy their thirst for blood.

A cross-country airliner, whose passengers include a nuclear physicist, a rocket expert, and a mathematical genius, is drawn beyond radar range by an unknown, unbreakable force.