Kaoruko and Kazumasa Harima are a separated couple with two children. They plan to divorce once their daughter, Mizuho, enters elementary school. One day, they receive devastating news of their daughter falling into a coma after a near-drowning accident at a pool. The doctors declare her brain dead with no prospect of recovery and the couple must decide if they should donate her organs to others in need or to wait until her heart stops beating.

现代人内心流失的东西，这家杂货店能帮你找回——
僻静的街道旁有一家杂货店，只要写下烦恼投进卷帘门的投信口，第二天就会在店后的牛奶箱里得到回答。
因男友身患绝症，年轻女孩静子在爱情与梦想间徘徊；克郎为了音乐梦想离家漂泊，却在现实中寸步难行；少年浩介面临家庭巨变，挣扎在亲情与未来的迷茫中……
他们将困惑写成信投进杂货店，随即奇妙的事情竟不断发生。
生命中的一次偶然交会，将如何演绎出截然不同的人生？
如今回顾写作过程，我发现自己始终在思考一个问题：站在人生的岔路口，人究竟应该怎么做？我希望读者能在掩卷时喃喃自语：我从未读过这样的小说。——东野圭吾