Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.

Deathly ill Count Dracula and his slimy underling, Anton, travel to Italy in search of a virgin's blood. They're welcomed at the crumbling estate of indebted Marchese Di Fiore, who's desperate to marry off his daughters to rich suitors. But there, instead of pure women, the count encounters incestuous lesbians with vile blood and Marxist manservant Mario, who's suspicious of the aristocratic Dracula.