A fatalistic car crash in Mexico city sets off a chain of events in the lives of three people: a supermodel, a young man wanting to run off with his sister-in-law, and a homeless man. Their lives are catapulted into unforeseen situations instigated by the seemingly inconsequential destiny of a dog.

Based on the journals of Che Guevara, leader of the Cuban Revolution. In his memoirs, Guevara recounts adventures he and best friend Alberto Granado had while crossing South America by motorcycle in the early 1950s.