Vampyr is set just after the First World War and follows the story of a doctor who returns home to find his homeland ravaged by the Spanish Flu. After treating one of his patients, the doctor gets bitten, thus transforming him into a vampyr

The Daywalker known as "Blade" - a half-vampire, half-mortal man - becomes the protector of humanity against an underground army of vampires.

Vampire death dealer Selene fends off brutal attacks from both the Lycan clan and the Vampire faction that betrayed her. With her only allies, David and his father Thomas, she must stop the eternal war between Lycans and Vampires, even if it means she has to make the ultimate sacrifice.

The fourth season starts off with everything in transition. Elena faces her worst nightmare as she awakens from her deadly accident to find she must now endure the terrifying change of becoming a vampire — or face certain death. Stefan and Damon are torn even further apart over how to help Elena adjust to a life she never wanted, and everyone must cope with the chaos created after the vampires and their supporters were outed to the town council and local leaders. Despite everything, as Elena and her friends enter into the final stretch of high school before graduation sends them on different paths, they feel the bond to their home town of Mystic Falls take on a deeper meaning when a new mysterious villain is introduced who seems intent on destroying it.

Life hasn't been the same for Elena since the tragic death of her parents, but she tries to pick up the pieces and provide support for her troubled younger brother, Jeremy. On her first day back at Mystic Falls High School, Elena meets the mysterious new guy, Stefan, and the two seeming lost souls form an instant connection. What Elena doesn't know, however, is that Stefan is a vampire, constantly resisting the urge to taste her blood. But Stefan, it seems, has a greater evil to deal with when his dangerous older brother, Damon, shows up to wreak havoc on the town of Mystic Falls — and claim Elena for himself.

As the war between the vampires and the Lycans rages on, Selene, a former member of the Death Dealers (an elite vampire special forces unit that hunts werewolves), and Michael, the werewolf hybrid, work together in an effort to unlock the secrets of their respective bloodlines.

Vampires and werewolves have waged a nocturnal war against each other for centuries. But all bets are off when a female vampire warrior named Selene, who's famous for her strength and werewolf-hunting prowess, becomes smitten with a peace-loving male werewolf, Michael, who wants to end the war.

Having escaped years of imprisonment, vampire warrioress Selene finds herself in a changed world where humans have discovered the existence of both Vampire and Lycan clans and are conducting an all-out war to eradicate both immortal species. Now Selene must battle the humans and a frightening new breed of super Lycans to ensure the death dealers' survival.