Former London constable Nicholas Angel finds it difficult to adapt to his new assignment in the sleepy British village of Sandford. Not only does he miss the excitement of the big city, but he also has a well-meaning oaf for a partner. However, when a series of grisly accidents rocks Sandford, Angel smells something rotten in the idyllic village.

Vincent is an all-too-human man who dares to defy a system obsessed with genetic perfection. He is an "In-Valid" who assumes the identity of a member of the genetic elite to pursue his goal of traveling into space with the Gattaca Aerospace Corporation.

Five friends who reunite in an attempt to top their epic pub crawl from 20 years earlier unwittingly become humankind's only hope for survival.