A member of the English upper class dies, leaving his estate and his business to an American, whom he thinks is his son who was lost as a baby and then found again. An Englishman who thinks he is an Indian comes to believe that he is actually the heir. He comes to hate the American who is his boss, his friend, and the man who has stolen the woman after whom he lusts.

A U.S. satellite crash-lands near a small town in Utah, unleashing a deadly plague that kills virtually everyone except two survivors, who may provide clues to immunizing the population. As the military attempts to quarantine the area, a team of highly specialized scientists is assembled to find a cure and stop the spread of the alien pathogen, code-named Andromeda.