It's the biggest event of the year — the Super Bowl! But the star players for the Cougars, gathered in New Orleans for the big game, are preoccupied with some serious off-the-field issues. Dave Walecki's marriage to his wife Nancy is falling apart, while Jim McCauley is involved in a shady deal with a management firm that could destroy his career. But that's nothing compared to the real drama. There's an assassin killing off many of the team's personnel (as well as their chances of winning)!

Detective Rita Rizzoli is accustomed to donning costumes and going undercover to nail crooks. But she'll be required to use all of her get-ups and more when a major cocaine ring is suspected of turning out a potent new strain of the drug, called "Fatal Beauty." With the help of her partner and a former bodyguard for a local cartel, Rita will do whatever it takes to find out who's dealing Fatal Beauty and stop them.