The Duke Boys and company travel to Hollywood to sell some musical recordings in order to raise money to build a new hospital in Hazzard County. However, when their recordings and money are stolen, they wind up on the run from mysterious hitmen, sleazy record producers, Russian gangsters, and vicious loan sharks.

Set in 1954, a group of Florida high schoolers seek out to lose their virginity which leads them to seek revenge on a sleazy nightclub owner and his redneck sheriff brother for harassing them.