In Kyoto, Mayuko (Haruka Ayase) stands at a crossroad in her life. She's thinking about marriage with her boyfriend Kyoichi (Hiroyuki Hirayama). By an accidental opportunity, Mayuko stays at Honnouji Hotel. There, she meets historical figure Nobunaga Oda (Shinichi Tsutsumi) who is attempting to unify Japan.

Shinzo Egi is an asthma sufferer who does not want to be place on life support. As a last request, Shinzo Egi asks his doctor Ayano Orii if she could follow his wish. Doctor Ayano Orii is then questioned in a criminal case because of her decision.