In 1916, beautiful young mute Helen is a domestic worker for elderly, ailing Mrs. Warren. Mrs. Warren's two adult sons, Albert (a professor) and womanizing impudent Steven, also live in the Warren mansion. Mrs. Warren becomes concerned for Helen's safety when a rash of murders involving 'women with afflictions' hits the neighborhood. She implores her physician, Dr. Parry, to take Helen away for her own safety. When another murder occurs inside the Warren mansion, it becomes obvious that Helen is in danger.

A power struggle ensues after the death of media magnate Amos Kyne, whose corporation has been turned over to his sole heir, his foppish son Walter. Rather than run the company himself, Walter decides to let the heads of its three divisions fight it out for control. Their assignment is to score an exclusive on a serial killer who is terrorizing women in New York. The Kyne organization's newspaper dubs him "The Lipstick Killer." If a resourceful someone can identify him even before the police do, Walter Kyne will reward him with the title of executive director. One of the three, newspaper editor John Day Griffith, has an ally in high-profile reporter Edward Mobley, who also does reports on Kyne's television network. While wire-service chief Mark Loving recruits star writer Mildred Donner to be his eyes and ears, a third contender for the top job, Harry Kritzer, carries on a secret affair with Dorothy, who is Walter Kyne's wife....

Jeff Bailey seems to be a mundane gas station owner in remote Bridgeport, California. He is dating local girl Ann Miller and lives a quiet life. But Jeff has a secret past, and when a mysterious stranger arrives in town, Jeff is forced to return to the dark world he had tried to escape.

Three detectives in the corrupt and brutal L.A. police force of the 1950s use differing methods to uncover a conspiracy behind the shotgun slayings of the patrons at an all-night diner.

When Dr. Anthony Edwardes arrives at a Vermont mental hospital to replace the outgoing hospital director, Dr. Constance Peterson, a psychoanalyst, discovers Edwardes is actually an impostor. The man confesses that the real Dr. Edwardes is dead and fears he may have killed him, but cannot recall anything. Dr. Peterson, however is convinced his impostor is innocent of the man's murder, and joins him on a quest to unravel his amnesia through psychoanalysis.