S. Muthu (aka Smoothu) , who is a pickpocket expert, meets with an accident and after that incident, he starts to suffer from a disease, alien hand syndrome, which means that his left hand wouldn't be under his control. Now, what problems this syndrome creates and how does it bring about a change in Smuthu's life?

Malini, a docile nurse, is forced to move into her boyfriend Varun's house, where she is raped — twice — by his boss, and also sent to prison on false charges. When she comes to know who the person behind her predicament is, she plans revenge.