The story of Shikkar takes place at Chittazha, a mountainous terrain where bamboo reeds flourish. After much wandering from place to place, Balraman (Mohanlal) a lorry driver has finally settled down with his daughter (Ananya) at Chittazha. Peace evades the man as his past catches up with him, and Balaraman has to risk everything to safeguard his own life and that of his daughter's.

With the arrival of electricity in the region under the British rule, the Odiyan clan that possesses the supernatural powers to assume animal form find it difficult to survive as they are ruthlessly captured and killed by the British. How the last Odiyan tries to save his clan with his stealth attacks, forms the crux.