《音乐之声》的故事发生在1938年的奥地利萨尔兹堡，年轻活泼的修女玛丽亚·任纳尔(Maria Rainer)到退役海军上校冯·特拉普家，照顾他的七个孩子。冯·特拉普上校虽然冷漠严厉，但终究还是抵挡不住玛丽亚的纯洁善良，两人终于结婚，可惜刚刚渡完蜜月，他们的安静生活因被纳粹占领奥地利而破碎了。

7-year-old Bertil's parents are at work and Bertil are home alone and bored. He is the only child in the family since his sister Martha died of an illness. But everything changes when he meets little Nils Karlsson Pyssling and they become friends. Nisse who lives in the basement in a room he rents from the rat Tjofsan,wich is cruel.