The new science teacher Dr. Julian Olcott (Carl Schell) with a mysterious past arrives in an institutional boarding school for troublemaker girls. Along the night, the intern Mary Smith (Mary McNeeran), who is blackmailing another teacher - Sir Alfred Whiteman (Maurice Marsac) - with some love letters, is slaughtered by a werewolf. The detective in charge of the investigation attributes the crime to a wolf, while her mate Priscilla (Barbara Lass) believes she was killed by Sir Alfred. On the next days, other deaths happen in the school, reducing the list of suspects.

Tommaso Puzzilli is a boy who grew up in the suburb of Pietralata outside Rome. Not having a job, Tommaso and his friends are committing crimes to make money.