The origin story of former Special Forces operative turned mercenary Wade Wilson, who, after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.

Wisecracking mercenary Deadpool battles the evil and powerful Cable and other bad guys to save a boy's life.

When the renegade crew of Serenity agrees to hide a fugitive on their ship, they find themselves in an action-packed battle between the relentless military might of a totalitarian regime who will destroy anything – or anyone – to get the girl back and the bloodthirsty creatures who roam the uncharted areas of space. But... the greatest danger of all may be on their ship.