La Ciudad de las Estrellas, a tiny town in the South American jungle, is home to an understaffed, understocked medical clinic where three idealistic doctors come looking for change.

A Chicago-based wizard works as a private investigator.

Captain Mack leads an elite military unit on a search for a missing scientist, and comes face-to-face with an an ancient evil lying beneath the Middle Eastern desert. Evil that is not of this world. Evil that should never be unearthed.

An Iraqi war vet returns home to find that his brother is in a coma from participating in an illegal underground fight club.

The Pilot Episode, we are introduced to Harry Dresden, a resident Wizard who helps the Chicago Police solve mysterious crimes and protects mankind from the evil supernatural forces that surround us. A young boy comes to Harry looking for help and Harry eventually realizes that a Skinwalker, a demon that rips the flesh of its victims and takes their identity, is after the little boy. Harry must race to save the boy from this evil entity.