At her husband's funeral, Pearl, Jewish mother of two divorced and antagonistic daughters, meets an old Italian friend of her husband, whose advice years previously had stopped the husband leaving home. For 23 years he, now a widower, has secretly loved Pearl.

Upon hitting puberty, a high school boy realizes that he is homosexual and faces prejudice from his homophobic parents and friends.

After losing her job, making out with her soon-to-be former boss, and finding out that her daughter plans to spend Thanksgiving with her boyfriend, Claudia Larson faces spending the holiday with her unhinged family.

Dede is a sole parent trying to bring up her son Fred. When it is discovered that Fred is a genius, she is determined to ensure that Fred has all the opportunities that he needs, and that he is not taken advantage of by people who forget that his extremely powerful intellect is harboured in the body and emotions of a child.