Ren Feifan, heir to the renowned traditional Chinese medicine clinic Kuiyi Hall, returns home after serving four years in prison for a crime he did not commit. Determined to uncover the truth behind the conspiracy that destroyed his family, he begins investigating the forces responsible while working to restore his family's once-respected legacy.

民国江云镇豆腐老板诡异惨死，小女孩撞见亡母坐红衣花轿现身。落魄侦探奉命查案，意外发现本该葬身猪笼的大太太死而复生，伪装出马仙复仇，顺带揪出豪门鸦片走私黑幕。