In the summer of 1982, as all of Staten Island anticipates the opening of a blockbuster boxing movie, an Italian-American family must confront its greatest challenges.

Writer and teacher Iris finds her comfortable, solitary New York life thrown into disarray after her closest friend and mentor bequeaths her his beloved 150 lb. Great Dane. The regal yet intractable beast, named Apollo, immediately creates practical problems for Iris, from furniture destruction to eviction notices, as well as more existential ones. Yet as Iris finds herself unexpectedly bonding with Apollo, she begins to come to terms with her past, and her own creative inner life in this story of healing, love, and friendship.

Jack Linden (Mark Ruffalo) and Hank Evans (Peter Krause) are best friends who both teach at the same university in a small New England town. They both have young children and Jack's wife, Terry (Laura Dern) is close with Hank's wife, Edith (Naomi Watts). But while things appear happy on the surface, there are smouldering pockets of discontent underneath. Financial struggle and domestic boredom has drained the passion from Jack and Terry's marriage, while Hank's numerous infidelities and self-absorption has prompted Edith to find both comfort and sexual fulfilment with Jack. As Jack begins spending more and more time with Edith, it becomes obvious to Terry, whose anger culminates in a sexual encounter with Hank. Now that the deception has come full circle, both couples are left to decide the futures of their shattered unions...

Ellie Parker, an aspiring actress from Australia, lives a hectic Hollywood lifestyle, perpetually trying to land the role that will elevate her career. Living with her lothario musician boyfriend, Justin, Ellie is far from happy, finding support primarily from her friend Sam. But when Ellie meets Chris after a minor traffic accident, she sees new potential for both romance and her life in general.

A teenager transitions from female to male, and his family must come to terms with that fact.